Interestingly, serine levels showed a higher positive log2FC-change in aus-type rice, while OAS levels were unaltered in tolerant genotypes but decreased in sensitive genotypes (Fig. 4).
Western blot analysis confirmed that Rb phosphorylation is decreased in sensitive cell lines after PD 0332991 treatment, while resistant lines that had detectable pRb were relatively resistant to the effects of PD 0332991 on Rb phosphorylation.
However, if the two tests employed are highly sensitive, the decrease in sensitivity is expected to be marginal and less than the difference among currently available screening tests [17].
For example, in contrary to our sequencing data, the expression levels of osa-miR408 transcript were reported to decrease significantly in sensitive rice cultivars, whereas they remain elevated in the tolerant rice cultivars at different time points of dehydration stress (1, 3 and 6 h) [ 58].
Sodium-driven alveolar fluid clearance (AFC) was reduced in CAP1/ Prss8-deficient mice, due to a 48% decrease in amiloride-sensitive clearance, and was less sensitive to β2-agonist treatment.
Of note, RITA failed to increase, but rather decreased, DR5 in sensitive samples it, which argued against the involvement of the p53 pathway in cell death.
In both species there was a significant decrease in NEM-sensitive ATPase activity with increase in salt concentration and an increase in activity with increase in ammonia (P < 0.003).
10.7554/eLife.06126.020 Figure 7. VASP-depletion leads to a decrease in tension-sensitive actin polymerization at focal adhesions.
This change in gene expression is specific for basal mammary stem/progenitor cells, is associated with proliferation defects in vitro and in vivo, and is probably caused by an early parity-induced decrease in hormone-sensitive and Wnt4-secreting luminal cells.
However, RITA had a trend to decrease DR5 expression in sensitive cells (p = 0.07, Pearson test, Figure 4D).
