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Tolerance manifested as a decrease in seizure threshold to near-control values, while withdrawal hyperexcitability was evidenced by a significant decrease in seizure threshold below the control value.
A decrease in seizure latency and an increase in seizure severity were also observed.
While CBZ was ineffective in all animals, VPA induced, during treatment, a progressive decrease in seizure frequency in animals primarily suffering from non-spreading neocortical seizures, but was ineffective in animals with a high frequency of spreading seizures.
Moreover, quantified saponins-rich fraction at 4 mg/kg dose showed significant increase in latency to clonic convulsions, decrease in seizure severity and increase in average wave amplitude in bicuculline, BAY k-8644 and veratridine tests, respectively, as compared to vehicle control.
They may alter the excitability of the hippocampus, potentially underlying the decrease in seizure threshold seen with estrogen treatment and across the estrous cycle, as well as the estrogen-dependent increment and facilitation of LTP [39], [41], [42].
However, a dose of 150 μg/kg resulted in a significant decrease in seizure latency.
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The observed decrease in seizures could lead to reduced neurological disabilities and epilepsy associated with malaria in this area.
An observed decrease that is similar to the predicted decline estimated by malaria-attributable fractions for seizures would suggest that the decrease in seizures observed is a measure of seizures that are attributable to malaria.
The observed decrease in acute symptomatic seizures was similar to the predicted decline that was estimated by malaria-attributable fractions for seizures in 2002 and supports the hypothesis that the decrease in seizures during a period of a reduction in malaria transmission is an approximate measure of seizures that are attributable to malaria.
We examined the changes in the incidence of admissions with seizures over a 7-year period and used the decrease in the incidence of malaria to calculate malaria-attributable fractions for seizures to determine if the observed decrease in seizures was a measure of the childhood admissions with seizures that are attributable to malaria.
In addition, at Years 1 and 3, respectively, 56 (40%) of 139 and 35 (47%) of 74 patients who had a ≥50% decrease in seizures at 3 months and had remained in the study were now seizure-free (100% responders), indicating a clinically relevant sustained or increased response.
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