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Cohort II showed a marked percentage decrease in recommendations for RP and EBRT as first treatment option.
Physician recommendations for extended endocrine therapy changed for 26%% of patients after considering BCI results, with a net decrease in recommendations for extended endocrine therapy from 74 to 54 %.
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Presumably, the decrease in recommendation for RP or EBRT in the later cohort was due to the above-mentioned shifts in the patients' age structure and risk profile and because of the introduction of AS and HIFU as new treatment options in 2005.
The only exception to manufacturer recommendations was the decrease in the total reaction volumes from 50 μL to 10 μL.
Our results show a significant decrease in VAP influencing three of the recommendations established to prevent this type of adverse event (assessment of sedation level, semi-recumbent position and prophylaxis of deep venous thrombosis).
A metabolic response was defined as a decrease in SUVmax>25%, as per EORTC recommendations (Young et al, 1999).
This period has seen increasing rates of twin pregnancies and decreasing rates of higher order births which have coincided with changes in recommendations regarding assisted reproductive techniques.
These results are inconsistent with our first hypothesis, since ethnicity did not lead to an obvious decrease in the quality of medical decisions or recommendations.
We note that if we do not allow this, the resulting recommendation networks show a decrease in navigability the more items a user has already rated.
However, recent recommendations have led to a decrease in transfusion triggers [ 21].
This recommendation might partially explain the slight decrease in HAART uptake and consequently, the slight increase in AIDS risk for the period 20052006 in our study.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com