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This probably explains a decrease in pulse rate with fimasartan.
Thus, the decrease in pulse rate may be caused by concomitant statin therapy.
Most likely, this slight decrease in pulse rate is due to increased baroreceptor sensitivity exerted by AVP [ 36, 37].
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Our study results are consistent with those of a larger panel study in Seattle (Mar et al. 2005), but that study did see minor decreases in pulse rate in healthy subjects.
Cardiovascular system observations included a decrease in SBP and an increase in pulse rate.
Slight increases in pulse rate and slight decreases in blood pressure were observed in patients taking lesogaberan compared with those taking placebo, in line with results from previous studies.
Canagliflozin was also associated with significant decreases in systolic BP (with no compensatory increase in pulse rate) and increases in HDL-C, but showed modest, dose-related increases in LDL-C.
Second, an orthostatic increase in pulse rate of 20 beats per minute and a decrease in systolic blood pressure of 10 mmHg.
On the other hand, the decrease in RPP after oral nifedipine administration was not less than 12,000 bpm × mmHg, which could be due to the fact that an increase in pulse rate with nifedipine by reflex tachycardia.
No clinically meaningful changes in pulse rate were observed.
No patients reported any abnormal changes in pulse rate.
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