Sentence examples for decrease in population doubling from inspiring English sources

As the population doublings increased, telomeres shortened, the culture took longer to double, and rearranged telomeres were detected at a point coincident with a decrease in population doubling time.

The clones with combined H-RasG12V expression and p53 knockdown exhibited a significant decrease in population doubling time (Figure 3B), and a loss of cell to cell contact inhibition (Figure 3C).

In addition to the above α-dependent proliferation rate, we introduced an α-independent apoptosis rate increasing linearly with time to account for the experimentally observed decrease in population doubling rates from 1.0 to 0.5/d for 0.0, 0.5, and 0.7% DMSO and from 1.0 to 0.2/d for 0.9 and 1.1% DMSO, respectively (unpublished data, see also Methods).

A significant decrease in population doubling (PD) rate is seen in Nfkb1 −/− MEFs compared to Nfkb1 +/+ with increasing time in culture (Fig. 3A).

As population doubling time was measured every day, the decrease in population doubling time that occurred during the evolution experiment (Fig. 2a) could be compensated for by transferring smaller aliquots at the later stage of the experiment.

This and the fact that the changes in doubling time were stably inherited even after freezing and reviving strongly suggest that the decrease in population doubling time is a consequence of mutations that fixed in the experimental populations, and not simply a physiological adaptation to the new conditions by means of gene regulation.

Most of the reduction in population doubling time occurred during the first 1000 generations and resulted from a marked decrease in age at first division (Fig. 2b).

These results demonstrate a dose-dependent decrease in population cell doubling after exposure to IR (Fig. 1B).

More importantly, inhibition of PKM2 induces a significant decrease in the population doubling (PDL) and cell proliferation rates, as well as an increase in cell size [50].

Population doubling times were calculated as previously, resulting in doubling times ranging between 15.6 h–27.1 h.

These changes in c-Myc protein level induced altered proliferation rates where increased c-Myc resulted in increased BrdU incorporation and decreased population doubling time, while c-Myc knockdown has the opposite effect (Figure S3).