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A small decrease in margin provides greater assurance of satisfactory effect, but the cost of the study will increase because more patients are required.
In this retrospective survey, the LDP group had a decrease in margin positivity rate but the tumor size was smaller compared with the ODP group and LDP was more likely to be performed at academic/research institutions.
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However, it seems unlikely that such a dramatic decrease in margins is on the horizon.
Not every business will be able to offset the decrease in margins with the increased purchase volume promised by one-click payments.
The company blamed the decrease in profit margin on low-margin contracts in emerging markets like Africa, South America and Asia, as well as its home market of China.
There was also a slight decrease in gross margin, which measures sales minus the cost of producing goods.
Harris, who is chairman and owns about 20% of the shares, said: "Like so many retailers, we are continuing to experience a very challenging trading environment, with significant sales volatility and a corresponding decrease in the margin".
A "decrease in the margin of safety" at Davis-Besse invites undue risk.
Across the different levels of API price, there is a decrease in profit margin from 2010 to 2012 of 7%.
Larger companies usually have larger facilities for development and expansion than smaller companies and are more likely to survive any large decrease in profit margins.
Industry analysts said that while the company should not welcome any decrease in gross margins, this particular case was not as damaging as some circumstances -- for instance, if Sun were dropping prices for its servers amid a price war.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com