Sentence examples for decrease in lifespan from inspiring English sources

It seems clear that for some people--perhaps many--having a chronic disease does not cause a decrease in lifespan.

On the other hand, experiments in invertebrates have shown an increase in oxidative stress, with a concomitant decrease in lifespan, in animals that undergo a lifelong increase in physical activity [35], [36].

Whether l(2 08717 symporter activity maintains lysosomal pH and leads to better survival during IH is not known at this time, but previous studies in flies have shown that gene mutations linked with lysosomal trafficking pathways lead to synaptic dysfunction, neuronal degeneration and decrease in lifespan in adults [40], [41].

Conversely, decreasing pch-2 expression with RNAi led to a decrease in lifespan.

We investigated further neuronal targets to identify cell types that could be responsible for the decrease in lifespan.

Notably, only two of the genes tested from this group caused a decrease in lifespan upon knock-down.

In N2 worms, we observed no negative effects of GE on lifespan at concentrations of 0.1%, 1%, or 2%, while significant decreases in lifespan were observed for 4%and1010% GE (Fig. 4A).

Male rictor +/− mice had a significantly decreased lifespan, with a 40% decrease in median lifespan compared to wild-type controls (Fig. 1A, Table S1 and S2 in Supporting Information).

It is important to note the unexpected decrease in mean lifespan when heavy alcohol consumption is lowered and the slight increase in longevity when non- and very light drinkers decrease.

When expression is limited to cholinergic neurons, Aβ1 42 results in a 38.1% of decrease in mean lifespan relative to control (log-rank P<0.0001, Fig. 1A) suggesting a significant Aβ1 42 neurotoxicity.

Of the RNAi experiments with single genes, dhhc-11 showed a decrease in mean lifespan.