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The patient with PD was the only one without a decrease in lesion size.
Moreover, addition of apocynin to the drinking water of AS mice produced a decrease in lesion size as compared to untreated AS mice, with the effect most pronounced in the thoracoabdominal aorta but absent from the aortic arch.
In this study, all patients with SD had a decrease in lesion size, meaning that the treatment had a beneficial effect.
Response was evaluated as the time to "improvement", as defined by any decrease in lesion size, lesion number, or edema.
In vivo treatment with DETC in BALB/C mice infected with Leishmania braziliensis caused a significant decrease in lesion size (p<0.0001), paralleled by a 100-fold decrease (p = 0.0087) in parasite burden.
For evaluation of response, "improvement" was defined as any decrease in lesion size, lesion number, or lesion-associated edema noted in the clinical charts, to reflect AIDS Clinical Trials Group (ACTG) KS response criteria [17].
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The 2 3% reductions in plaque index observed in this study at 3 months appear relatively modest when compared to decreases in lesion size of greater than 30% observed over a similar time frame in some animal studies.
In addition, two categorical measures of improvement, average change, and percentage change in lesion size (>10% decrease, >25% decrease, and >50% decrease) at various visits, were tabulated and the two groups compared.
Clinical down staging in axillary status was necessary; SD was defined as a decrease of less than 50% in the sum of the products of measured lesions, or an estimated decrease of less than 50% in lesion size or an increase of less than 25%, without the appearance of new lesions.
The environment after trauma is dynamic and cell death persists for weeks following SCI [37] [39] resulting in an increase in lesion size and a decrease in the spared tissue around the injury.
The direct causal role of C3aR1 is provided by the fact that pertubaration of this gene in knock out mice models result in significant decrease in atherosclerotic lesion size [ 14].
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