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Viewpoint 12 has both increase and decrease in interactions in approximately the same magnitude (~50 %).
Improvements in treatment may have led to a decrease in interactions resulting in fewer patients meeting the definition.
These data indicate that for this subset of DJ-1 familial mutations, the decrease in interactions with aSyn is due – at least in part – to decreased expression levels, which is likely representative of what occurs in patients.
Summary of median magnitude of change, direction, and number of df DIRs for viewpoints 1, 2, 11, and 12. Notice how viewpoint 1 displays an increase in contact probabilities with surrounding sequences (64%% of total detected regions), while viewpoints 2 and 11 show mostly a decrease in interactions (60%% for viewpoint 2, and 95%% for viewpoint 11).
A decrease in interactions between males and females (social sniffing and ultrasonic vocalization) has been observed in Shank3-deficient mice (Bozdagi et al., 2010), whereas no difference, or a trend towards a decrease in the interactions, have been reported in two different cohorts of the same Shank3-deficiency model (Yang et al., 2012).
Viewpoints 3, 4, and 9 show a ~50%% split between regions with an increase and decrease in contact probabilities, while the rest of the viewpoints show a variable range in the decrease in interactions (60 79 % of total regions per viewpoint).
Similar(54)
Thus, while there are examples of increased affinity of IDPs for interacting partners, growing evidence also suggests a decrease in interaction affinity upon phosphorylation, especially of S/T residues as is observed in the case of PAGE4/c-Jun interaction in the present study.
The DPRS predictions showed little or no decrease in interaction force with increasingly conforming profiles.
Nuclear proteins showed an inverted behavior: a decrease in interaction density both using PIN and the hypergeometric model.
The Ku70D192R/R194D/D195R mutant did not show a decrease in interaction with TRF1, despite a robust interaction and comparable protein expression levels.
The competitive effect due to the addition of the cognate sugar showed a drastic decrease in interaction energy (Fig. 5), with most of the curves exhibiting no adhesion, confirming the specificity of the interaction.
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