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Interestingly, KAN-1 also showed a decrease in focus numbers, but at the same time, an enlargement in size.
Ten days after incubation in 10 μg/ml and 100 μg/ml P. indica root aqueous extracts, GBM8401 cells showed diminished focus formation, and HeLa cells showed marked decrease in focus formation after 100 μg/ml P. indica root aqueous extract treatment compared to untreated cells in both cell lines.
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Furthermore, it is observed that a slight decrease in foci intensity appears on the field profile with a more random nanohole array.
A subset of these samples (n=CL-5; RS=13) were analysed at 24 h post-IR and showed a further decrease in foci number, approximately to background levels.
However, after 48 h post radiation we clearly observed a decrease in foci for pmiR-210 A549 cells compared with pmiR-Ctl cells (5.6±1.2 versus 10.8±3.3; Figure 5c).
Six of 10 patients show a marked increase in γH2AX foci formation following a PET scan exposure, 1 patient had a marked decrease in foci formation after the scan, and 2 patients displayed no change.
During the 24-h monitoring, the decrease in foci number was significantly slower in XRCC4-mutant fibroblasts (XRCC4 m/m #1, from individual II-1; XRCC4 m/m #2, from individual II-2) compared to that in wt cells, whereas at the endpoint, the differences became statistically non-significant (Fig 2A).
Depression has been found to influence work performance with significant decrease in task focus and productivity [ 59].
A relative decrease in γH2AX foci number per Gy and an increase in foci overlap was exhibited at 4 Gy.
Furthermore, SPOP-wt increased RAD51 foci formation compared to controls, while SPOP-F133V-expressing cells showed a dramatic decrease in RAD51 foci formation, consistent with impairment of HDR.
Histologic analysis of spinal cords collected from EAE rats at peak of disease (day 12 post-immunization) revealed a decrease in inflammatory foci (Fig. 6d), suggesting that PEG-HCCs reduce immune cell infiltration into the central nervous system.
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