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Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas.
The studies showed that ketamine was responsible for a decrease in connectivity in the brain regions responsible for pain sensing and affective processing [ 26, 27].
Critically, Petersen and colleagues describe that oral contraceptives as well as endogenous sex hormones are associated with a decrease in connectivity in the resting state network (Petersen et al., 2014).
Petersen and colleagues describe a decrease in connectivity in oral contraceptive users and luteal women, suggesting the synthetic hormones in oral contraceptives and endogenous sex hormones have a similar effect on connectivity in the resting state (Petersen et al., 2014).
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We find that longitudinal increases in reading ability are associated with higher initial connectivity in the dorsal stream between fusiform and inferior parietal cortex, implicated in phonological decoding, followed by decreases in connectivity in this stream over time.
In contrast the urbanisation scenario resulted in a decrease in connectivity, with a 39% decrease in the IIC.
Post-hoc, a paired T-test within the ArchT group (post-laser vs. pre-laser) confirmed a significant decrease in connectivity (p = 0.014).
This resulted in a 19% decrease in connectivity density (Conn.D).
There was a decrease in connectivity strength in early-stage stroke compared to HC, but no significant differences in connectivity between early stroke and PR and between PR and HC.
This significant decrease in connectivity for words mirrors the increase in laterality illustrated in Figure 1 b.
However, our study suggests that at least part of this decrease in connectivity can be manipulated pharmacologically.
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