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Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas.
In contrast the urbanisation scenario resulted in a decrease in connectivity, with a 39% decrease in the IIC.
Interestingly, the identified learning related decrease of activity in the left and right BA44 and the l-IPL was not related to an increase or decrease in connectivity between these areas.
This resulted in a 19% decrease in connectivity density (Conn.D).
However, our study suggests that at least part of this decrease in connectivity can be manipulated pharmacologically.
This significant decrease in connectivity for words mirrors the increase in laterality illustrated in Figure 1 b.
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Decreases in connectivity reflected improvements in symptoms, as reported by the patients.
We find that longitudinal increases in reading ability are associated with higher initial connectivity in the dorsal stream between fusiform and inferior parietal cortex, implicated in phonological decoding, followed by decreases in connectivity in this stream over time.
Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected).
Although differences in integration and marginal correlation were detected, all ROI selection schemes reliably detected decreases in connectivity within the DMN for the rest to a working memory transition.
As can be seen in Figure 5, the dominant effect in the pattern of age-related decreases in connectivity is represented by the communication between the hemispheres (right/left and left/right quadrants).
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