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A limitation of many global climate models with explicit finite-difference numerics is the timestep restriction caused by the decrease in cell size associated with the convergence of meridians near the poles.
A decrease in cell size may be associated with cytoskeletal reorganisation.
Addition of the whole TSP-1 resulted in a decrease in cell size along with increased granularity (data not shown).
Thus the increased rate of division in myogenic cells constitutively expressing Pax3 or Pax7 was coupled with a decrease in cell size.
Wing analysis of these flies showed that this is mostly due to a decrease in cell size as the cell number seemed to be little affected (Figure 9).
Figure 6B demonstrates that myostatin inhibition induced an approximately 20% increase in cell size, while myostatin overexpression resulted in an approximately 20% decrease in cell size.
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For higher concentration of ZnS nanoparticles, decrease in cell sizes due to drastic loss of storage deposits is observed (Fig. 4c, d).
The treatment of HepG2 cells with CE was also noted to induce a decrease in cell sizes.
FLJ10540 overexpressed clones were decreased in cell size and appeared to be more spindle-shaped and had increased intercellular separation compared to vehicle control clones, which were round-shaped (Figure 2A, middle panel).
Increased expression of inhibitors of mTOR, such as REDD1 and REDD2, have been linked to decreases in cell size and protein synthesis and have been suggested to promote muscle atrophy [ 20, 21, 26, 41].
Notwithstanding this caveat, the effects of TOR inhibition on protein synthesis were large and rapid and preceded decreases in cell size, suggesting that the loss of cell mass after TOR inhibition is likely to be due to the reduction in protein synthesis.
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