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The signal is transduced inside the cells and the nucleus, leading to down-regulation of adhesion-associated genes and corresponding adhesive proteins, resulting in decrease in cell adhesion and causing cells to detach, float, and shrink in size.
We attribute the decrease in cell adhesion to the propensity of the ordered mesoporous carbon films to sorb organics from aqueous solution, which could lead to removal of adhesion-promoting compounds at the film surface.
The increase in axonal outgrowth induced by sAPPα and sAPPβ is likely linked to the decrease in cell adhesion.
MTLn3 cells lacking cortactin expression (si) exhibited a 50% decrease in cell adhesion compared to control (Ctl) cells.
Therefore they concluded that the decrease in cell adhesion molecules was associated with the increase in tumor cell proliferation and might contribute to invasive ability of meningioma.
The effects of sAPPα and sAPPβ on axonal outgrowth that we observe here are associated with a decrease in cell adhesion that is similar to what has been described for heparan sulfate on primary neurons [19], [20].
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The COMT Val108/158Met genotype demonstrates a strong trend towards predicting the range of the NRG1α-induced adhesion response with risk homozygotes having decreased variation in cell adhesion even in normal subjects (p = 0.063).
Since β-catenin pools involved in both processes are interchangeable, an increase or decrease in β-catenin involvement in cell adhesion would affect pools available for Wg signaling, subsequently readjusting the Wg pathway efficiency (Valenta et al., 2012).
Preliminary PCR array experiments indicated that inhibiting MP1 expression leads to decreased expression of molecules involved in cell adhesion in MCF-7 cells, including several integrins (data not shown).
Interestingly, this subnetwork shows a unique involvement of genes related to extracellular matrix interaction and cell migration, with decreased expression of genes involved in cell adhesion and increased expression of genes implicated in motility and invasion, thus unveiling the presence of characteristics of epithelial-mesenchymal transition (EMT).
The early recruitment of DCs to the lymph node is essential for the proper initiation of an immune response, and we previously reported that As exposure decreases the expression of genes involved in cell adhesion and migration (Kozul et al. 2009).
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