Sentence examples for decrease in arthritis severity from inspiring English sources
In IL-17R deficient mice, a decrease in arthritis severity was characterized by increased synovial apoptosis, reduced proliferation and a marked reduction in synoviolin expression.
More importantly, we observed a significant decrease in arthritis severity from day 44 following injection of 1 × 10 cells.
In this study, we observed a significant decrease in arthritis severity after blocking CD97, especially when treatment was initiated in early disease.
These findings indicate that the reduction in arthritis severity in NMU-KO mice was due neither to impaired differentiation nor a decreased inherent functional capacity of the main innate immune cell types that contribute to the multistep pathogenesis of arthritis in this model.
We found that the dramatic increase in arthritis severity was caused by a decreased capacity of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex to produce ROS.
All studies showed an improvement in arthritis severity with the addition of glucocorticoids to antibiotics.
Dr Christine Plater-Zyberk (Munich, Germany) described the validation of an anti-GM-CSF monoclonal antibody (22E9) for the treatment of RA, and noted how administration of this antibody decreased arthritis severity in several experimental models [ 28- 30].
After a plateau between day 0 and day 8 in both untreated rats and HA-treated AIA rats, the body weight rose in concomitance with the decrease of arthritis severity.
Therefore, we evaluated whether selective targeting of MKK7 using anti-sense oligonucleotides (ASOs) would block arthritis-associated JNK activation and decreased arthritis severity in K/BxN serum transfer arthritis.
As previously described [25], compared to WT mice, IL-17R −/− mice had reduced synovial hypercellularity leading to significantly decreased macroscopic arthritis severity scores (Figure 7A, mean ± SEM score 1.5±0.17 in WT versus 0.31±0.10 in IL-17R −/− mice; P<0.05).
In these experiments, Col-Treg clones (1 × 10 cells per animal) reduced disease severity as shown by a decrease in arthritis score and prevented body weight loss.
