Some reports corroborates this statement, as demonstrated by Meymandi et al. [ 36] where clearly showed that, at their histological findings, there was a reduction in aggregations of histiocytes, decreased cellular parasitic load and an important increased numbers of CD3+ T cells in response to combining antimonial treatment.
We observed not only a 30% decrease in aggregation (Amax), but also slowing of this process by over 35%, resulting in the lengthening of the time required to reach the aggregation maximum by about 20%.
It seems that incubation with the rc peptide leads to a significant decrease in the aggregation of Aβ peptide.
The binding of L. johnsonni to mucins results in aggregation of Helicobacter pylori, decreased H. pylori load, and facilitation of the clearance of the pathogen, thereby suggesting that the binding of such bacteria to mucins may play a role in gastrointestinal homeostasis.
Weakening of such interactions, e.g., by httNT phosphorylation, results in decreases in aggregation propensity, aggregate stability, and disease toxicity.
A-Beta interaction with TTR resulted in a decrease in the aggregation state of the peptide as well as in its toxicity [8], [18].
Results indicated three-dimensional conjugated structures can efficiently decrease the aggregation of materials, resulting in the improving of the light-emitting efficiency.
Authors report that 8 weeks of treatment with triptolide in five-month-old 5XFAD mice decreased the aggregation of Aβ in the brain by altering the processing of its precursor protein (amyloid precursor protein, APP).
For example, the decrease in surfactant aggregation number upon addition of 1 mM CD at constant total surfactant concentration was about double for HP-β-CD compared to α-CD.
