Universal prestorage leukoreduction has resulted in decreased fever episodes and antibiotic use after RBC transfusion, with a reduction in mortality [ 4].
In the list of strongest decreases, fever, streptococcal infections and concussion can be traced back to altered views in medical management.
If such associations were to be confirmed, experimental studies would be needed to evaluate whether decreasing fever duration with antipyretic treatment could affect patient outcomes.
No statistically significant difference was found regarding the period of decreasing fever, of the hospitalization's duration in patients with one, two or more organ dysfunctions with or without of identified etiologic agent.
Bernard et al. [ 10] reported that, in patients with sepsis, treatment with ibuprofen reduced levels of prostacylin and thromboxane and decreased fever, tachycardia, oxygen consumption, and lactic acidosis, but did not prevent the development of shock or acute respiratory distress syndrome, and did not improve survival.
All included trials reported side effects or adverse events such as paresthesia, weight decrease, anorexia, fever, fatigue, upper respiratory tract infection, somnolence, allergy, and traumatic liver injury.
We compared the duration of the antibiotic course with: 1) the IDSA guidelines that recommend to use the decrease of fever and the need for surgical debridement and, 2) a theoretical duration if a PCT-based algorithm has been applied.
When groups of acute malaria patients infected with P. falciparum were treated with allopurinol in addition to the anti-malarial drug quinine, a significantly faster decrease in fever levels and splenomegaly was observed compared to the group of patients treated only with quinine.
Minocycline was administered on day 8 and resulted in a gradual decrease in fever and rash.
On day 4, the exanthema had spread systemically, and treatment with minocycline was started, which led to a gradual decrease in fever and rashes.
