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Decrease dose or interrupt treatment depending upon severity of cytopenias.
Treatment techniques have continued to evolve dramatically and techniques such as IMRT and proton therapy are specifically designed to decrease dose and injury to tissues surrounding malignant tumors.
In patients with small intestine or other critical structures adjacent to targets, the PTV was subtracted from the organs at risk to decrease dose to the organs at risk.
Two adjustments "do not change dose" and "decrease dose by up to 1 unit" were the most common adjustments in both patient (51% and 15% respectively) and computer-generated dose adjustments (62% and 20%).
We recorded for each drug: a) the amount of pills actually purchased every month, as recorded in the electronic pharmacy database; b) the amount of medication supposedly consumed, recorded in the nurse reports; c) physicians' recorded medication decisions, i.e. change of regimen/dosage (stop, increase or decrease dose, or start a new medication).
Alfacalcidol uniquely required more orders to increase drug dose than decrease dose (142/281 of alfacalcidol orders vs. 46/121 for calcium carbonate and 38/230 for all other medications, Table 3), thereby reflecting a very high level of non-adherence for this drug.
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Nanoformulations applied in biomedicine and agriculture are designed to decrease dose-dependent toxicity by the reduced amount of an applied compound, which is realized by increasing the solubility of poorly water soluble active ingredients, enhancing their bioavailability, targeted delivery, controlled release, and/or protection against degradation.
To improve the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) and decrease dosing frequency, polyethylene glycol polyglutamate block copolymers were used as delivery carriers.
In addition to achieving these synergistic effects, the combinations of two or more compounds are essential for the following reasons: (1) to prevent or suppress the emergence of resistant strains, (2) to decrease dose-related toxicity, as a result dosage, and (3) to attain a broad spectrum of activity [ 28].
The polymer molecular weight increases with decreasing dose rate and increasing monomer concentration.
The absorbance of Fe2+-ferrozine complex significantly decreased dose dependently (1 10 mg/ml).
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