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Do not increase or decrease dosage on your own.
Simply slowly decrease dosage as comfortable until you are no longer reliant on the drug.
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Increasingly, combinations of agents are being used to achieve synergistic inhibition of viruses, to delay resistance, and to decrease dosages of toxic drugs.
Before the off-target effects could be eliminated by novel HIV protease inhibitor scaffolds, the development of HIV protease inhibitor prodrugs could decrease dosages and meliorate the side effects.
NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result in abnormal development of atrioventricular septa.
Dissection of this phenotype in zebrafish embryos revealed a complex genetic architecture: dosage perturbation of four genes (ASGR1, ACADVL, DVL2, and GABARAP) impeded neurodevelopment and decreased dosage of the same loci caused a reduced mitotic index in vitro.
Engineering of this binding site in BoNT/A leads to mutants with >3-fold increased potency, which can be exploited as new therapeutics with decreased dosage and thus might prolong the period until immune response in patients.
Formulation considerations of a new drug delivery system include controlling the site of release of the active ingredient, maintaining drug level for a suitable time and decreasing dosage frequency.
Despite alloantibody presence in five patients, eight patients remain without the need for specific treatment and only sirolimus monotherapy in decreasing dosage.
The high image quality ratings recorded for fast imaging opens other possibilities such as a combination of decreased dosage of the administered radiopharmaceutical and fast imaging, which is now accepted as a compromise in our current use of DMI.
In females, we observed a trend toward increased LOH with decreased dosage of Slbp (Figure 1B).
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