Sentence examples for decrease differentiation from inspiring English sources
Thus an increase in available TLE in the nucleus might be expected to inhibit self renewal and decrease differentiation.
81 Further, estrogen-related receptor alpha was shown to decrease differentiation of human mesenchymal stem cells into osteoblasts, osteopontin expression, and mineral deposition, but to increase adipocyte differentiation.
Besides having an inhibitory effect on apoptosis, CYT1 has also been found to induce chemotaxis (Kainulainen et al, 2000) and to increase proliferation and decrease differentiation in rat adrenal gland pheochromocytoma cells (Veikkolainen et al, 2011).
Myocardial injection of miR-24 improved heart function and attenuated fibrosis and, notably, overexpression of miR-24 in cultured cardiac fibroblasts was also able to decrease differentiation to myofibroblasts through a reduction in TGF-β secretion and Smad phosphorylation [ 58].
Creg1, cellular repressor of E1A-stimulated genes 1, encodes a protein that antagonizes the activity of the adenovirus E1A protein, which functions to increase proliferation and decrease differentiation [ 80, 81].
In models of single colonic crypts composed of stem cells, differentiated cells and transit cells, increased proliferation, decreased differentiation or decreased apoptosis all lead to a net increase in cell number (67).
This effect resulted from a decreased differentiation and resorbing activity of osteoclasts and increased osteoclast apoptosis.
The down-regulation of both E-cadherin and β-catenin was correlated with decreased differentiation and increased tumour grade.
Pharmacological inhibition of PKCs or PKDs led to a markedly decreased differentiation of C2C12 cells.
This finding is important and supports observations of increased ROS, lipofuscin and decreased differentiation potential from aged mesenchymal stem cells [57].
Consistently, in Klf-9-null mice decreased differentiation and plasticity of adult born neurons elicit anxiety which is also only detectable in a dark-light-paradigm and not in other anxiety-related tests [32].
