Exact(2)
Red and blue areas correspond respectively to substructures that, on average, enhance or decrease compound bioactivity.
Finally, we intended to assess which substructures always increase or decrease compound bioactivity on human COX-1 and COX-2.
Similar(58)
Significant sorption occurs for the reactive components, and sorption increased with decreasing flow rate and decreasing compound solubility.
We also found that apoptosis and autophagy were simultaneously induced by compound 8 in HL60 cells, and inhibition of autophagy by 3-MA decreased compound 8-induced apoptosis, indicating that they acted in synergy to exert tumor cell death.
Compounds 1 and 2 exhibit ligand-centered luminescence but the intensity decreases; compound 3 shows the characteristic emission of Eu3+ ion and at the same time it retains the ligand-centered luminescence.
The distribution of fractional changes for decreasing compound concentrations is shown in Fig. 4 d.
Cold (20°C) stimulation at LI11 decreased compound 48/80-induced 48/80-induced mice.
Furthermore, the ionization efficiency in the ESI source is improved due to both decreased compound polarity and reduced matrix suppression.
Demyelination of axons results in decreased nerve conduction velocity (NCV), and loss of axons causes decreased compound motor action potential (CMAP) (Franssen, 2008).
Axonal forms of Charcot Marie Tooth disease are thought to originate on the neuronal side and are linked to decreased compound muscle action potential amplitudes.
Compared with traditional moxibustion, which uses high thermal stimulation of acupoints, the application of 20°C at LI11 also significantly decreased compound 48/80-induced 48/80-inducedhaviour in mice.
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