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One goal in drug design is to decrease clearance due to metabolism.
MCrAlY coatings are good candidates for abradable seals used in compressors of aircraft and industrial gas turbines to decrease clearance between the stator casing and rotor blade tips and hence to increase turbine efficiency and decrease fuel consumption.
It is unclear whether fibroblast growth factor-23 (FGF-23) increases in response to phosphate accumulation or to decrease clearance in chronic kidney disease (CKD) as is the case with other low molecular weight proteins such as cystatin C (CysC).
For example, ritonavir has been shown to decrease clearance and increase effects of alprazolam [ 13].
Therefore, metformin intoxication may either increase liver lactate production or decrease clearance (along with gluconeogenesis) [ 13, 16].
ADAMTS13 deficiency may decrease clearance of excessively released ULVWF multimers, leading to spontaneous microvascular platelet thrombi formation and multiple organ failure.
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In a paper published today in Science, Bateman calculated that it would take 10 years for this decreased clearance to cause the build-up of amyloid-beta that is normally seen in the brains of Alzheimer's patients.
The model begins with Aβ42 overproduction and aggregation, with decreased clearance, followed by plaque formation.
This phenomenon is exaggerated with the introduction of a moving ground which concludes that larger lift forces and longer wakes are apparent with decreasing clearance.
Indeed, Tpl2 ablation ameliorated macrophages response to LPS [28, 49], increased susceptibility of mice to Listeria monocytogenes infection [50], and decreased clearance of Toxoplasma gondii [51].
He told the BBC that copper also led to more protein being produced: "It's a double whammy of increased production and decreased clearance of amyloid protein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com