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Here we show that heterozygous dOpa1+/− mutations not only perturb eye function, but also decrease cardiac function and decrease escape responses under stress.
On the other hand, overly deep levels of anesthesia may decrease cardiac function and organ perfusion.
During model establishment, IgG purified from actively immunized rats was administered to rats to observe the effect of β1-AABs on cardiac function and we found that β1-AABs could decrease cardiac function.
Chronic exposure to elevated FFA reduced PPARα in cardiomyocytes, and this effect was proposed to further decrease cardiac function and increase intracellular fat stores [ 21].
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Conclusions: A preconceptional aortic diameter of 40 mm or more, progression of dilatation and decreased cardiac function are risk factors in pregnancy for women with the Marfan syndrome.
Type 4 CRS describes a state of chronic kidney disease (e.g., chronic glomerular disease) contributing to decreased cardiac function, cardiac hypertrophy, and/or increased risk of adverse cardiovascular events.
The "obesity paradox" is confined to older persons, with decreased cardiac function, less cardiometabolic illness, and recent-onset HF, suggesting that aging, HF severity/chronicity, and metabolism may explain the obesity paradox.
Studies in humans revealed early and persistent alterations of myocardial structure and decreased cardiac function detected by echocardiography in fetal, neonatal and juvenile patients with IUGR [15 17].
Yap CKO mice had robust increases in cardiomyocyte apoptosis and cardiac fibrosis that were associated with decreased cardiac function, indicating a critical role for Yap in maintaining adult heart homeostasis [122].
Notably, the "protective" association of BMI with mortality was confined to persons with older age (>75 years; hazard ratio [HR]: 0.82; p = 0.006), decreased cardiac function (ejection fraction <50%; HR: 0.85; p < 0.001), no diabetes (HR: 0.86; p < 0.001), and de novo HF (HR: 0.89; p = 0.004).
Treated mdx (26.2±3.1%) mice also showed significantly decreased cardiac function compared to treated (p<0.01) and untreated (p<0.05) wild type mice.
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