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"Combine this with cold air, which causes arteries to constrict and decrease blood supply, you have a perfect storm for a heart attack," he says.
Anti-angiogenic agents work mainly by suppressing vascularization to decrease blood supply to the tumor and arrest its growth.
In the current setting, blood screening for the presence of VL would decrease blood supply by 5%, negatively impacting on the blood supply provided by HEMOBA/SESAB.
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Ischemic neuropathies are those disorders in which nerve compression leads to decreased blood supply and subsequent damage to the Schwann cells.
Our results indicated that tumor cells in the hypoxic environment try to maintain the oxygen metabolism against decreased blood supply similar to the misery perfusion which has been observed in steno-occlusive disease in the brain [10, 16].
This may result in fluid accumulation in the chest and abdominal cavity as well as depletion of fluid from the circulation and decreased blood supply to vital organs.
The exception to this rule is prolactin: if a tumor compresses the pituitary stalk, a decreased blood supply means that the lactotrope cells, which produce prolactin, are not receiving dopamine and therefore produce excess prolactin.
Peripheral artery occlusive disease (obstruction of the arteries of the legs) occurs mainly in people with FH who smoke; this can cause pain in the calf muscles during walking that resolves with rest (intermittent claudication) and problems due to a decreased blood supply to the feet (such as gangrene).
It is recommended that magnetic resonance imaging (MRI) scan of the pituitary gland is performed if the diagnosis is suspected; this has a sensitivity of over 90% for detecting pituitary apoplexy; it may demonstrate infarction (tissue damage due to a decreased blood supply) or hemorrhage.
Indeed, if CKO mice have endothelial-driven angiogenic defects, such defects may result in a decreased blood supply to the fetus and uterine incompetence and could lead to delayed development and death at early post-implantation stages.
Another possible mechanism of this decreased blood supply is direct endothelial cell damage in vessels supplying tumors [ 28].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com