Sentence examples for decrease affinity for from inspiring English sources

The caffeine resistance mutations in TOR1 decrease affinity for caffeine or confer increased TORC1 kinase activity.

The modest distortion suggested that the FARS2 mutation would widen the ATP binding pocket and thus decrease affinity for ATP (Fig. S1).

When the three side chains are subjected to site-directed mutagenesis, with the sole exception of mutant Asn272 → Gln, various other replacements for Asn272 either markedly decrease affinity for the substrate (i.e., high KD) or abolish binding altogether.

Somatic mutations of the CREBBP cluster within the substrate-binding pocket of the acetyltransferase domain and have been shown to decrease affinity for their substrate, acetyl-coA, resulting in a net reduction in the H3K18 acetylation mark.

Of all the ligands investigated, only the benzoxazinone-based antagonists had decreased affinity for [A318G]OTR.

The Bcl-xL mutants, with decreased affinity for Bim, caused an increase in apoptosis and a corresponding decrease in cell proliferation.

We demonstrate that the acquired resistance of chemically modified T. litoralis Sh1B DNA polymerase to DNA uracil correlates with its decreased affinity for template-strand uracil.

The increased transport capacity of alanine across the cell membrane and decreased affinity for transport sites of tyrosine indicates the involvement of two major amino acid transport systems (L- and A-system) in children with autism.

For example, peptides with modified MHC anchor residues that show decreased affinity for I-Ek have been identified to function as partial agonists of the TCR [76].

The decreased affinity for the NA substrate MUNANA was also reflected in the observed IC50 values for the NA inhibitors oseltamivir, zanamivir, and peramivir.

The H2A phosphorylation upon losartan would also influence the chromatin structure because it would lead to a decreased affinity for HP1α.