Sentence examples for declining hCG from inspiring English sources
Declining hCG measurements were well fitted by the model.
As previously, declining hCG values observed during the first 50 MTX treatment days were fitted using the Maximum A posteriori algorithm in NONMEMTM software.
The population pharmacokinetic model developed by the French national centre in 2010 was used to fit declining hCG measurements from data of patients extracted from the Charing Cross Hospital database (You et al, 2010).
Among these, a previous study led by the French reference centre for treatment of GTN (Centre de Référence des Maladies Trophoblastiques, Lyon, France), showed that mathematical modelling of individual declining hCG measurements using a population kinetic approach is feasible, and that derived parameters were strong early predictors of MTX resistance (You et al, 2010).
Declining hCG levels suggest no complications.
Therefore, intensive serum hCG monitoring is mandatory to detect impending treatment failure and/or inadequately declining serum hCG concentrations [ 13, 14].
In the UK trial, however, surgical intervention is installed in both treatment groups if inadequately declining serum hCG concentrations occur after one week of follow up.
It is possible that our study suffered from a similar bias, overestimating the true β-hCG clearance time as once a declining β-hCG is established, the frequency of determinations decreased meaning that the true time of clearance is missed.
Using a cutoff of 90% certainty at the second visit, according to this model, surgery is advised in patients with an initial serum beta-hCG level of 2,000 IU/l or higher which is rising, while a declining beta-hCG level under these restrictions could be interpreted as acceptable.
The red line indicates patients with a rising beta-hCG at the second visit, and the blue line indicates patients with a declining beta-hCG.
The second visit is taken into account by defining a dummy variable which indicates a rising (red line) or declining (blue line) beta-hCG.
