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"We are going to impose a mandate on existing products. . . to answer the question that people have been posing for years: whether you have declining efficacy, and whether that declining efficacy can lead to addiction," Gottlieb said in an interview.
"We are going to impose a mandate on existing products. . . to answer the question that people have been posing for years: whether you have declining efficacy, and whether that declining efficacy can lead to addiction," Gottlieb told our colleagues.
However, instead of reformulating the vaccine whose declining efficacy Merck itself has acknowledged, the company reportedly launched a complicated scheme to adjust its testing technique so that it would yield the desired potency results.
The WHO director-general called the declining efficacy of antibiotics a "security threat". It's not as simple as reducing the nation's massive antibiotic consumption.
In the light of this declining efficacy, Malawi is changing its first line therapy again.
Finally, the declining efficacy of PZP with increased consecutive applications is likely a contributing factor to the later foaling dates of recipient mares.
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Declining efficacies of azoles have also been reported in other fungal cereal pathogens, e.g. Septoria tritici and Blumeria graminis [ 6, 7].
This strategy is, however, hindered by relatively weak activity of some cellular promoters, which may lead to low levels of gene expression, thus declining therapeutic efficacy.
In addition, some treatment regimens unchanged for decades might be declining in efficacy because of drug resistance.
Over the course of many hours, however, synchrony invariably reemerged, even when feedback was used to compensate for declining cholinergic efficacy.
WHO recommends artemisinine combination based therapy (ACT) to overcome P. falciparum drug resistance, but reports of declining ACT efficacy have been published.
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CEO of Professional Science Editing for Scientists @ prosciediting.com