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Overall, the declines in functioning after transplantation were less pronounced than anticipated.
Participant and companion ratings were concordant in the control, low, and medium groups with both participants and companions reporting declines in functioning over time.
Frailty is a clinically recognised geriatric syndrome characterised by declines in functioning across an array of physiological systems. 1 Common symptoms of frailty are weight loss, exhaustion, low physical activity, slow walking speed at 'usual pace' and low grip strength.
As WNV continues to affect older age groups, further research should consider ways to control for declines in functioning associated with the aging process and to obtain objective data regarding baseline status.
Co-morbidity more common in old age, and age-related declines in functioning and sensory impairments, contribute toward making pain management especially challenging in this population [ 9, 10].
Moreover, differentiation between age-related declines in functioning and those that are disease-related requires normative data (i.e., BASFI in 'normal' general populations as opposed to patient groups).
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The control group who did not participate showed decline in functioning.
Understanding the role of muscle strength as a preventive factor for shorter-term declines in function may provide further insights into the disabling process.
Self-care is often linked with overall health-promotion strategies, including nutrition and exercise to maintain or prevent declines in function.
Up to 40% (and no less than 17%) of women experienced declines in function during the 12-month study period.
These declines in function that accompany adaptation – tradeoffs – are often considered inevitable costs or constraints of adaptation [ 1].
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