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In the present study, in vitro test results show that ZnO NPs imposed distinct toxic effect on LTEP-a-2 cells, and the declines in cell viability and survival rate coincided with specific morphological changes and the occurrence of apoptosis.
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However, PS exposure could not be identified to the same extent on rBHK-21host cells despite a similar decline in cell viability between rBHK-21host and BHK-21native batch cultures.
A silver nanoparticle dose-dependent decline in cell viability of consortium and individual isolates was compared under UVC and dark conditions to evaluate the antibacterial activity of the nanocomposite.
In the conventional Photosan group, cells incubated for 2 h in the presence of 5 mg/L photosensitizer showed a gradual decline in cell viability as light doses increased from 2.5 to 10 J/cm2, with significant differences at different light doses.
After a 24-h exposure, a 25% decline in cell viability was observed in Vero cells exposed to 50 μg/ml of 10-nm uncoated Ag-NPs (Figure 1).
To rule out the possibility that the reduction in cytokine production by these peptides was related to peptide-induced decline in cell viability, the cell survival was measured after six hours of LPS-stimulation.
When compared to free RV and HRP NPs, HRP RGD NPs can result in greatest decline in cell viability under all test concentrations, likely due to the stability and RGD targeting effects of HRP RGD NPs to PANC-1 cells [30, 31].
However, doxycycline-induced decline in cell viability was substantially blocked in K13-expressing cells (Figure 5A).
Treatment of vector-expressing BCBL1-TREx-RTA cells with doxycycline led to a decline in cell viability, which was consistent with the induction of lytic replication (Figure 5A).
Indeed, while the strain that expressed both SYWT and α-Syn showed a continuous decline in cell viability, the strain with combined expression of SYR621C and α-Syn maintained cell viability from the fourth day onward.
More importantly, exposure of MX2 cells to a combination of 20 µM menadione and genipin (concentration as low as 10 µM) resulted in a sharp decline in cell viability (Figure 1D).
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