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When there is no strong drive mechanism such as gas cap and/or aquifer, the production declines corresponding to the reservoir pressure decline.
If this view is correct, then we should observe age declines corresponding to d = 1.0 or more.
Given that age declines in recall are about 1 SD (d = 1.01 [23]; d = 0.97 [24]), if Craik is correct then we should observe age declines corresponding to d = 1.0 or more on prospective memory proper.
The mean level of CX3CL1 also declines corresponding to the decreased concentration of TNF-α (a weaker stimulator of CX3CL1 production).
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At low rates (<1 s−1), the temperature increased up to a strain of ca. 3, with the subsequent decline corresponding to an upturn in the stress.
A biphasic decline involves a fast initial phase (which roughly corresponds to the eradication of cycling cells by the drug), followed by a second and slower phase of exponential decline (corresponding to awakening and death of quiescent cells), which helps explain clinical data.
Although there are general patterns of decline corresponding to the natural history of specific dementia types, clinicians cannot rely on biomarkers (yet) or tissue grading/staging to guide diagnosis, targeted management, or prognosis.
The same trend of greater percentage biomarker decline corresponding with improved clinical outcomes held true for median times to treatment failure, with the exception of the (0 25%) and (26 50%) subsets.
We conclude that the progressive, age-related increases in DNA methylation at the 5' sequences of these genes could contribute to the observed age-related decline in corresponding mRNA levels.
Bouchon's "factor 2" reflects the breakpoint in the cognitive decline curve corresponding to clinically diagnosed AD, corresponding to around 70 years of age.
Figure 1, which presents the ANES Trust in Government and External Efficacy Indices from 1958-2012, illusthetes the broader trend of declining trust and the corresponding decline in external efficacy (the belief that individuals can influence government).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com