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These episodes lead to declined lung function and concomitant acute deteriorations in respiratory health [1].
Several patients displayed declined lung function (Patient 3, Patient 4 and Patient 5).
Altogether, the specific role played by P. pulmonicola in declined lung function is difficult to determine since it is associated with the chronic colonization of P. aeruginosa.
Research shows that RSV infection during infancy is an independent risk factor for declined lung function (peak expiratory flow rate measured by forced spirometry) in the following years with evidence suggesting a residual impact for as long as 18-20 years when compared to controls (OR: 5.27; 95% CI: 1.60 17.40) [ 85].
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Long-term adherence to self-monitoring of peak expiratory flow rate (PEFR) is essential for early detection of declining lung function in individuals with asthma.
Not sure if this hospitalization will be the one when signs of progression, a declining lung function, start to show.
This increased risk may be a consequence of declining lung function in patients with diabetes.
Both PAP and PAH also respond well to HSCT and repeated lung infections or declining lung function should be considered an indication in clinical context 53.
Although many other bacterial species persist and grow in the CF lung, chronic Ps. aeruginosa infection correlates with declining lung function and high mortality rates [ 4, 9].
Importantly, 1-year efficacy data for pulmonary function measures provide additional information on the effects of nebulized bronchodilator treatment against a background of naturally declining lung function.
86– 88 Treatment with sirolimus or everolimus is now recognized as the standard therapy for patients with declining lung function, symptomatic chylous effusions, lymphangioleiomyomas, or large AMLs.
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