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Pre-MCI decline trajectories, though, probably vary between individuals.
A combination of genetic and environmental factors may influence decline trajectories.
These data suggest mtDNA signatures might affect intrinsic cognitive decline trajectories.
Two deviated visibly by accelerating the rate of decline (trajectories in red).
By this reasoning, those with the most cognitive reserve and slowest decline trajectories are more likely to develop clinical AD at older ages than those with less cognitive reserve and faster decline trajectories.
Given equal pre-MCI cognitive decline trajectories, low cognitive reserve individuals will cross dementia thresholds before high cognitive reserve individuals.
Apolipoprotein E (APOE) alleles influence AD related-markers in ways potentially relevant to pre-MCI cognitive decline trajectories (Small et al 1995; Reiman et al 1996; Caselli et al 1999).
However, the modeling of more complex patterns of change over time [ 24] (e.g., J-shape curves for viral load following acute infection, CD4+ T-cell count decline trajectories, latent variable analysis) may provide phenotypes that are superior to those examined to date.
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Regardless, there may be a wide gap in the population decline trajectory between the point at which overfishing occurs and the point where the absolute risk of extinction becomes a real concern (Musick, 1999a).
All must hope that they are not stuck on a decline and fall trajectory.
Russian experts, however, predict a declining trajectory in the medium term.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com