Sentence examples for decline of the bone from inspiring English sources

Haematological grade 3/4 toxicities were increased when gemcitabine was administered as the second line compared with LV5FU2-CDDP: 58% in Arm A versus 33% in Arm B (p = 0.004) probably because of a decline of the bone marrow due an intensified first line.

With increasing age, a conversion from this highly cellular marrow in children to fatty marrow in adults occurs with a gradual increase of the bone marrow signal on T1-weighted MR images and a gradual decline of the bone marrow signal on STIR- or fat saturated T2-weighted MR images over time.

The sex of this skeleton was assessed as male on the basis of cranial morphologies, such as anterior decline of the frontal bone, projection of the superciliary ridge, inferior prominence of the mastoids, and developments of the superior nuchal line and the external occipital protuberance.

Programs of senescence have been extensively studied particularly during passage of human MSCs, and these may provide clues to the mechanism of age-related decline of MSCs in the bone marrow [ 44].

Both, a continuous decline of bone parameters throughout the chronic phase of immobilisation as well as stabilisation of bone status on a low level have been documented.

In the present study, the significantly altered functions of bone marrow MSCs from the mutant mice in the in vitro culture experiments strongly suggest that the functional decline of bone marrow MSCs after LRP6 deletion contributes directly to the skeletal defects in the mutant mice.

In summary, we showed that supplementation with high dose pulse therapy with cholecalciferol in HIV-patients with low 25OH vitamin D level resulted in a decline of bone resorption as well as in bone formation markers.

With the use of 2D slices, 3D images are reconstructed, in order to know the evolution and a state of decline of bone microstructure with aging.

The decline in total bone marrow hematopoietic cells is accompanied with elevated adipocytes into the marrow cavity, thereby inhibiting hematopoiesis and recovery of the bone marrow microenvironment.

SPARC-null mice exhibit early-onset cataracts [ 19], osteopenia-like decline of bone formation [ 20], increased obesity, and decreased skeletal muscle mass [ 21].

31 In this study, we investigated Cel treatment in female rats without RA and estrogen deficiency background, and found significantly elevated osteoclast surface and a decline of bone mass as well as BMD.