Our study provides evidence that not only an age-related decline of renal function but also the type of skeletal injury may contribute to the circulating concentrations of cFGF-23.
Efforts are underway to determine whether interventions capable to slow down, stop, or reverse structural progression of the disease will also prevent decline of renal function and improve clinically significant outcomes.
Ureters: dysmenorrhea, dyspareunia, urinary symptoms, hydronephrosis, flank pain, decline of renal function [2, 3].
With regard to the role of lithium exposure in the decline of renal function, the absence of a control group has to be taken into account.
Numerous clinical studies defined proteinuria as a major marker of the decline of renal function.
Renal fibrosis correlates with decline of renal function and is one of the causes of impaired renal function.
Proteinuria is a major marker of the decline of renal function and an important risk factor of coronary heart disease.
In the PREVEND study, the relation between albuminuria and decline of renal function in subjects without known risk factors, was only observed in those individuals with macroalbuminuria [9].
Moreover, adequate management of anaemia may slow the decline of renal function [ 17].
Hypercholesterolemia is a major determinant of decline of renal function in patients with diabetes [ 3].
The primary endpoint is decline of renal function at 12 months.
