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Synapses are destroyed in numerous other neurological diseases, including Alzheimer's, in which the gradual decline of memory function is likely due to loss of synapses in the hippocampus, and major depressive disorder, which is known to involve altered synapse function in the prefrontal cortex.
Earlier studies showed that cluster headache patients have a decline of memory processing during headache attack, but not between attacks and no progressive cognitive decline was detected [41].
In fact, LTD may significantly determine the efficacy of learning and memory by limiting acquisition and favoring the decline of memory [7], [8], [9].
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive decline of memory and cognition.
It usually manifests as decline of memory, attention, language ability, and social interaction [ 15– 17].
Functional MRI is a useful tool in predicting decline of memory after anterior temporal lobe resection.
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The diagnosis requires the presence of cognitive decline (loss of memory and deficits in at least two other domains) resulting in impaired functional abilities.
All measures revealed: (1) an overall decline of working memory performance with age; (2) a greater age-related decline of working memory performance with higher memory loads, regardless of the type of information; (3) no evidence that spatial working memory was more affected by age than color working memory.
Patients with more impaired executive functions may have a more rapid decline of immediate memory and a poor response to the rehabilitation of delayed memory.
Therefore, our results further demonstrated the impairment of the frontoparietal working memory network in PI, which might account for the reported decline of working memory capacity in sleep disorders [ 66].
It also appears to be charting the decline of my memory.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com