The present study, based on a network perspective, demonstrates a decline of structural integrity with preserved functional organisation of the motor network in ALS.
At the molecular level, there is for instance a gradual increase in molecular damage and heterogeneity (Rattan 2006, 2010), gradual malfunctioning of the cellular control systems (Hubbard et al. 2012), and decline of the integrity of mitochondrial constituents (Passarino et al. 2010).
It is noteworthy that the removal of salivary gland secretion results in significant decline of the functional integrity of the esophageal mucosa in an experimental animal model.
The increased microglial response to an inflammatory stimulus in G3 mTerc−/− mice is likely mediated by a decline of blood brain barrier integrity and increased immune cell infiltration upon telomere shortening.
The initial stages in the case of speciation would be characterised by increased frequency of mutation, which over several generations would decline as integrity of replication increased and the new home attractor increased in robustness, both features that would be subject to selection for fitness.
Our findings reporting on cortical thickness, white matter integrity and functional connectivity, strongly suggest a decline of structural motor network integrity in ALS.
However, the growth of polycrystalline diamond on the periphery of the seed crystal and the cracking generated by the internal stress during the growing process lead to significant decline of the quality and integrity of the CVD diamond, thus increasing the difficulty of synthesizing large diamond layers.
Haack, in particular, frames criticism of Rorty along these lines in moral terms; to her mind, Rorty's efforts to abandon the basic concepts of traditional epistemology are symptoms of a vulgar cynicism, which contributes to the decline of reason and intellectual integrity that Haack and others find to be characteristic of much contemporary thought.
"All of these nasty cases of food-safety problems are enough to show that lack of integrity and moral decline have become a very serious problem," Prime Minister Wen Jiabao told government officials in mid-April, according to The People's Daily.
The recommendations single out four main areas of abusive conduct that contributed to the "decline of public confidence in the integrity of the I.P.O.
