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The main measurement of success was a composite that took into account deaths from the disease and the decline of functionality.
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Whilst mobility scooters may help to improve the quality of life of their users, it is also possible that the sedentary nature of their usage results in a decline of physical functionality and therefore reduced capabilities.
Indeed, several data demonstrated that different excitotoxic insults induced apoptosis in a p53-dependent manner, leading to progressive decline of neuronal functionality and finally cellular death.
Aging is usually defined as a time-dependent decline of maximal functionality that affects tissues and organs of the whole body and leads to an increased susceptibility to disease and risk of death [ 1].
Overall, these observations led to the idea that longevity may arise from a particularly efficient process of maintenance of the cellular and organismal activities that could contrast the inevitable time related decline of the organism functionality, which in turn leads to death.
Caring for someone with a chronic condition can be a risk factor as it can impact on functioning or lead to an acceleration of decline in functionality (Vitaliano, Young, & Zhang, 2004).
Interestingly, Twilio's emergence on the Google platform comes at a time when Google has declined to offer this kind of functionality for its own telephony services.
In addition the 3 patients who had corticosteroids withheld experienced no significant decline in functionality, two had ECOG scores of zero and one had an ECOG score of 1.
There is associated decline in functionality and reduced independence, plus increased risk of injury and joint stiffness [ 17].
Moreover, the age-related decline in the functionality of the immune system (immunosenescence) [5] is characterized by a chronic low-grade inflammatory status (inflammageing) [6] [8].
And this ensures a kind of functionality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com