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The hard fact of aging is the body's decline of function: Muscles lose strength and mass, bones become fragile, the heart beats slower, and brain function becomes impaired before death.
mTOR-dependent hyperfunction and hypertrophy of beta-cells, may eventually culminate in cell loss and decline of function [ 177, 178].
A decline of function in the neuromuscular junction has long been thought to contribute to the decline of muscle mass with age (Bütikofer et al., 2011).
Within this framework the neurobiological reason for the distinct time course of decline of function is selective vulnerability of brain regions.
A premature invo-lution of the thymus and a decline of function of T cell-dependent immunity is inherent in OXYS rats [ 15, 16].
The non-linearity of the decline of function impedes the calculation of effect sizes based on cumulative values from these multidimensional scales.
Similar(48)
Decline of functions, malfunctions and atrophy are secondary.
Secondly, objective factors of burden that are related to disease symptoms (e.g. problem behaviours and the decline of functions).
The individual assessment of these dimensions is meant to identify individual risk factors or a decline of functioning, leading to a need for individual intervention strategies.
This could be the result of mechanisms that buffer, adapt, or remodel, leading to only a negligible decline of functioning initially (see e.g. Rattan 2006).
The early initial prodromal state was operationally defined by either basic symptoms predicting psychosis [ 10] or by a clinically relevant decline of functioning in combination with established risk factors (risk and decreased functioning) [ 22].
More suggestions(19)
decline of performance
decline of work
decline of job
reduction of function
decline of employment
decline of authority
decline of responsibility
decline of functionality
decline of jobs
decline of functional
decline of labor
decline of civilization
decline of spanking
decline of wildebeest
decline of chanting
decline of party
decline of poetry
decline of deterrence
decline of productivity
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