Huang et al. conclude that the decline in p53 functionality in senescent cells is due to changes in upstream signaling that ultimately leads to destabilization of p53 and abrogated signaling.
The results further support the idea that cell depolarisation indicates a decline in cell functionality due to energy depletion, but does not involve cell death.
During coral exposure to elevated temperatures, the photosynthetic machinery of endosymbotic dinoflagellates is susceptible to heat impairment [ 45, 47], especially the D1 protein [ 48, 49], resulting in a decline in PSII functionality [ 50, 51].
Several clinical studies have shown that acute myocardial infarction (AMI) causes a decline in the social, physical and psychological functionality of affected patients [ 1- 12].
Several studies have reported a decline in HSC functionality and a differentiation bias toward myelopoiesis with age.
We therefore explored the possibility that the bet-1 lf and smo-1 lf mutants are experiencing a decline in muscle functionality.
Expression of all of these genes was substantially downregulated in aged versus young cTECs (Fig. 4A; see supplementary material Fig. S5 for gating strategy for flow cytometric analysis and sorting of TEC subsets, and validation), consistent with an age-related decline in TEC functionality.
Aging is characterized by progressive declines in the physiology and functionality of adult tissues and can manifest nine common hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication.
Any associations documented in older populations are likely to be more pronounced among younger groups, as older individuals may expect a certain amount of decline in health and functionality as a normal part of the experience of growing older.
Caring for someone with a chronic condition can be a risk factor as it can impact on functioning or lead to an acceleration of decline in functionality (Vitaliano, Young, & Zhang, 2004).
