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As an improvement in sensitivity necessarily means decline in specificity, and vice versa, we chose the cut-off which ensured equal sensitivity and specificity in the development population.
Finding transcription factor binding sites first (alignment free) means that it is not possible to use evolutionary conservation for that step, and a decline in specificity may be the result.
We hypothesized that this decline in specificity was an artifact of our study design, i.e. was due to cross-contamination between sputum specimens resulting from difficulties in splitting the viscous material.
We tested the hypothesis that the observed decline in specificity was due to cross-contamination between sputum specimens during the splitting procedure by comparing sensitivity and specificity of the sputum test over time in the 83 specimens that were not split on day 1, and were tested without CPC on days 4 and 7.
In contrast to previous studies, the simulation results suggest that prevalence estimates based on PCR genotyping assay results generally overestimate the true infection burden; genotyping assay sensitivity has limited effect on the composite prevalence estimates; and the decline in specificity is more influential.
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This interaction was the result of a significant decline in memory specificity from pre- to post-manipulation in individuals reporting high levels of rumination about symptoms when depressed who were allocated to the analytical condition.
However, we agree that complete substitution of DAP for adenosine may cause specificity to decline in certain sequence contexts, which may limit its usefulness in microarray applications.
The weaker signal modules (M4 M7) show a high level of specificity but a decline in sensitivity starting at 20% noise.
Furthermore, we found no evidence for increased risk for decline in QoL, and overall the sensitivity, specificity and predictive values of the geriatric screening tools were low.
Prenuptial agreements have grown in specificity.
The thrice-weekly list has evolved in specificity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com