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VSV replication was sensitive to this stress with significant decline in replication process.
Notably, a decline in replication fork rate is known to be consistent with increased rates of local origin activation and higher replication fork densities, indicating that RITA stalled DNA replication elongation and affected replication fork rate.
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They are inherent: age-dependent declines in replication and differentiation remain evident in most clones derived from single preadipocytes cultured in parallel from animals of different ages for over a month (Djian et al., 1983; Kirkland et al., 1990).
This conversion is usually associated with a dramatic decline in viral replication.
Researchers have speculated that declines in HIV replication capacity and virulence may be attributed to not only rapid adaptation to protective variants but also increasing use of antiretroviral treatments.
In replication replicators do not blend.
In particular, increases in parasite relatedness led to a decline in the optimal replication fraction as the interaction between closely related individuals intensifies.
Prior work had shown that p16INK4a tumor suppressor causes an age-dependent decline in beta-cell replication.
A small study of pancreata from twenty non-diabetic organ donors aged 7 to 66 showed a decline in beta cell replication with age [ 16].
Because CENP-A is required for cell division, the finding that it declines with age suggests the possibility that increased p16INK4A is not solely responsible for the decline in beta-cell replication with age, particularly in humans.
In a study of human pancreatic tissue by Reers et al., the decline in beta cell replication with age was not found to be associated with a change in the frequency of apoptosis [ 16].
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