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The AgNPs as contaminants effect a decline in proliferation of mouse spermatogonial stem cell (C18-4) (Braydich-Stolle et al., 2010) and cause mitochondrial dysfunction and induction of ROS which in turn set off DNA damage and chromosomal aberrations resulting in cell cycle arrest (Asharani, Lian Wu, Gong, & Valiyaveettil, 2008).
It, therefore, initiates a decline in proliferation of mesenchymal cells and promotes differentiation.
One is that these alterations in gene expression reflect a decline in proliferation of a muscle-associated cell such as the satellite cell.
This appears to correlate with the changes observed in RTE of older mice, which display a decline in proliferation and activation [ 7, 14].
Later in the cycle, ovulation occurs, and the ovary produces progesterone, which antagonises oestrogen, thereby causing a rapid decline in proliferation.
When mice were injected daily over a 3-week period with 13- cis RA the decline in proliferation induced by 13- cis RA treatment was primarily in the suprapyramidal blade (Fig. 4B, right).
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When compared to siCTRL-transfected cells, siAK2-transfected UM1 cells exhibited a 23% decrease of proliferation (p = 0.01), while siAK2-transfected UM2 cells showed a 24% decline in their proliferation (p = 0.003).
Increasing evidence has revealed that EZH2 has oncogenic properties, as an increased expression of EZH2 augments proliferation and invasion of cancer cells [ 92– 94], while depletion leads to a decline in cell proliferation, increased apoptosis, and inhibition of metastatic tumor growth in vivo [ 95, 96].
The marked decline in background proliferation found when subjects received IFN-α meant the use of the commonly employed stimulation index (ratio of specific proliferation to background proliferation) was not possible due to inflated elevations in the values [ 12].
These benefit from the additional use of bone marrow-derived mesenchymal stem cells, but these cells exhibit an age-related decline in lifespan, proliferation and osteogenic potential.
In elderly mice, studies showed that the population of actively dividing SVZ cells and the rate of interneuron replacement in the OB are both drastically reduced, indicating an age-related decline in neuronal proliferation and migration through the RMS.
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