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Gs-alpha activation resulted in larger embryoid bodies (EBs), due, in part, to increased cell proliferation and prevented the time-related decline in expression of transcription factors important for maintaining ES cell pluripotency.
The resulting inhibition of Wnt signaling within sorted TECs was confirmed by the expected decline in expression of known Wnt target genes including Axin 2 and c-Myc, although a decline in Wnt target genes could also be explained by a loss of specific TEC subsets that differentially express these genes.
The decline in expression of both chondrocyte markers coincided with the onset of late-stage chondrocyte differentiation.
This decline in expression of WIN4-like genes in plants treated with SD was most dramatic in bark.
We observed a decline in expression of the several floral homeotic genes, FT genes, auxin responsive genes in ripe fruit.
In murine sWAT, we observe a precipitous decline in expression of ucp1, the hallmark of a brown adipocyte, with advancing age.
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Racial attitudes in Britain, he concludes, are structured by generation, with a large decline in expressions of prejudice among those in the cohorts which have grown up since immigration began.
Together, these studies revealed conserved declines in expression of genes encoding components of the mitochondrial respiratory chain, suggesting some shared aspects of tissue aging among these diverse organisms [26], [27].
Finally, whereas N-Myc deficiency alone decreased the size of the epiphyseal head of the tibia (and other limb elements – not shown), and resulted in small declines in expression of Ihh, Runx2, Vegfa in the growth plate, it had a relatively strong effect on Col1 and Runx2 expression in the perichondrium, and on the thickness of perichondrium (Fig. 9IB, B', F, 9IIF).
First, there was a dramatic decline in expression levels of the basal cell-enriched genes upon induction of differentiation following the culture on ALI in parallel with acquisition of the morphologic phenotype of a ciliated airway epithelium.
Declines in expressions of positive affect and increases in negative affect show linear trajectories from early to mid-adolescence with a slight reversal in late adolescence; yet, levels do not return to those seen in early adolescence (Kim et al. 2001).
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