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A decline in auditory function is almost a default feature of aging, with over two-thirds of adults 70 or older afflicted by at least some hearing loss.
Graydon et al. [21] found a decline in auditory verbal memory following left unilateral temporal lobectomy and a decline in visuospatial memory following right unilateral lobectomy.
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Declines in auditory acuity [9] [10], temporal processing [11], memory [12], speed of information processing [13] [14] and the ability to filter out irrelevant competing auditory input [15] [16] also contribute to difficulties reported by older adults for hearing SIN.
We found that the average azimuthal tuning for the high frequency sound was actually less sharp than that for the low frequency sound (width at half-max: high = 42°±14°, low = 32°±12°; Fig. 4D,E), implying that the decline in the auditory system's capacity to encode IPD at high frequencies is more severe than the increase in the rate of change in IPD with sound azimuth.
In a silent environment, repeated exposure to sounds with identical features may induce neural adaptation and a consequent decline in the auditory-evoked response amplitude [ 21- 23].
In the Wisconsin study, type 2 diabetes and glucose intolerance were completely prevented and age-dependent decline in skeletal muscle mass, auditory function, and brain volume were significantly attenuated in DR monkeys compared with the ad-libitum control group (Colman et al., 2008, 2009; Someya et al., 2010).
Additionally, an exploratory analysis of regional effects uncovered age-related declines in both global and local efficiency concentrated exclusively in auditory areas (bilateral superior and middle temporal cortex), further suggestive of specificity to the speech perception tasks.
A possible explanation for the decreased intensity discrimination at low frequencies, and enhanced amplitudes with prolonged latencies in older subjects is an age-related decline in inhibitory control within the central auditory nervous system.
Our data demonstrated that d-gal-induced mimetic aging rats exhibited an accelerated accumulation of the CD and a gradual decline in the CcO activity in the auditory cortex during the aging process.
More than 50% of pediatric cancer survivors will develop long-term complications, including cardiovascular, gonadal, and gastrointestinal/hepatic dysfunction, neurocognitive sequelae, auditory complications, and decline in growth, with approximately 25% of cases being severe [ 290].
Leventhal has "really got something," agrees Donald Caspary, a neuropharmacologist at Southern Illinois University Medical School in Springfield whose group has found a similar decline in GABA-supported networks in the aging auditory system.
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