Sentence examples for decline and progression from inspiring English sources

These issues encompassed diagnostic challenges, management of kidney functional decline and progression of chronic kidney disease, challenges in clinical study design, translation of advances in research to clinical care, and provision of practical and integrated patient support.

Hippocampal overactivity is well-documented in patients with aMCI, and its occurrence predicts further cognitive decline and progression to Alzheimer's dementia, Gallagher said.

It has been shown that viruses binding to CCR5 are almost exclusively present during the early asymptomatic stage of the infection whereas CXCR4-binding viruses may emerge in later phases of the infection and are associated with a CD4+ T-cell decline and progression towards AIDS [4].

Patients with CF who have at least one CFTR mutation of this type are at high risk for early lung function decline and progression of other disease manifestations.

Our findings suggest a mechanism for the observed epidemiologic link between inflammation and risk of age-related cognitive decline and progression of neurodegenerative disorders including Alzheimer's disease.

Like LES, PES has been associated with a worse baseline lung function and nutritional status, increased rates of lung function decline and progression to end stage lung disease, and are more likely to be resistant to antibiotics [ 7, 13].

Chronic bacterial respiratory-tract infections are a major driving force in the pathogenesis of cystic fibrosis (CF) lung disease and promote chronic lung-function decline, destruction, and progression to respiratory failure at a premature age.

The study aims to address the lack of evidence guiding mobility rehabilitation for older adults by identifying those impairments and impairment combinations that are most responsible for mobility decline and disability progression over 2 years of follow-up.

More recently, pirfenidone and nintedanib, two compounds with pleiotropic mechanisms of action, have proven effective in slowing functional decline and disease progression in IPF patients with mild to moderate functional impairment, highlighting the importance of timely diagnosis and administration of treatment in early stages of disease.

This estimation supports the natural history model whereby viral replication drives CD4 decline and clinical progression (Figure 5a).

T-cell immune activation is known to play an important role in HIV pathogenesis and is linked to CD4+ T-cell decline and disease progression [48], [49].