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Data on the following outcomes were included: overall survival, progression-free survival, response rate (including complete and partial response), PSA decline, adverse effects of treatment, pain and health-related quality of life.
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As pH increased beyond 5.52, tannase activity declined suggesting adverse effect on tannase production.
Although human immunodeficiency virus (HIV related morbidity and mortality rates in patients treated with a combination of high active antiretroviral therapy (HAART) have declined, significant metabolic/vascular adverse effects associated with the long term use of HIV protease inhibitors (PIs) have emerged as a significant side effect.
Even among individuals who regard themselves as physically fit, negative stereotypes associated with older people's general physical decline may have adverse effects.
Phenacetin (Figure 2) is an analgesic, once widely used but nowadays its use has been declined because of its adverse effects.
Deficits in children's scores have been reported to be smaller at age 11 years than at age 8 years in a longitudinal study on malnourished children stunted children suggesting that adverse effects may decline over time [ 7].
28– 32 With older age, major life challenges are increasingly likely to occur, including declining health and functioning, with adverse effects on independence and social participation, social network losses due to illness and death of relatives, friends and neighbours and frailty or vulnerability to adverse outcomes.
However, one of the critical issues in trials of adjuvant therapy for cancer patients is whether the size of the survival benefit is worth the decline in QOL caused by adverse effects of treatment.
Correct: "There were adverse effects".
By establishing a model of the hydrological environment influencing A. sinensis spawning, [Zhang (2009]) considered that silt content in the river dropped dramatically after completion of the Three Gorges Project (TGP) in 2003, declining more than 90%, probably having adverse effects on A. sinensis natural reproduction.
Notwithstanding variation in survival, natality rates of 60% to 75% have been generally associated with stable or increasing populations of pinnipeds [20] [22], whereas rates of 55% or lower have been associated with declining populations and related to the adverse effects of density dependant factors or food stress [8], [23].
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