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GeoCities called their members homesteaders, yet with Twitter or Facebook there is no moniker by which to declare our association.
The threshold to declare an association significant was set at P < 5e-04 for the purpose of comparison between panels.
Nominal significance (P ≤5.00 × 10−2) was used to declare an association significant in the association analysis of the HLA-B alleles with BD (as the tests performed are not independent), and in the association of SNPs with BD (as these constitute replications of previously reported associations).
These efforts are further fueled by the challenge that the study power of any single cohort is limited given the high confidence threshold required to declare an association as genome-wide significance in the context of a large number of comparisons made in GWASs.
We used a family-wise error rate of 0.05 corrected for the number of tested SNP x expression associations, which corresponds to declare significant any association with a P-value <5.78×10−12.
The threshold to declare a significant association was set to –log10 P = 5.
No authors declare association that might pose a conflict of interest with the submitted work.
For testing and efficient plotting of small networks, one can declare association edges directly inside the URL parameter.
The authors declare no commercial association and no conflict of interests regarding this research and paper.
However, because rare variants are more numerous and less correlated with each other than common variants, a simple α = 5 × 10−8 threshold is not enough to declare significance in association studies that target rare variants.
However, the samples used to declare genome-wide association in each region are generally the same as, or a subset of, those used to generate the summary statistics used in our analysis, and we cannot alter a prior belief on the basis of the same data we are about to analyse.
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