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Instead, targeted phosphoproteomics would allow monitoring hundreds of phosphosites involved in particular pathways, thus decisively contributing to unambiguously identify defects causing the onset of the signaling pathologies.
The reconstruction of acquired facial defects and deformity resulting from trauma, burns, and tumor resection has always been a great challenge for surgeons as the head and neck region provides complex anatomy and essential functions decisively contributing to each patient's quality of life.
Thus, we have demonstrated that 17-AAG-dependent inhibition of NF-κB activity is tightly associated with transcriptional repression of Survivin and cIAP1 anti-apoptotic genes, thus decisively contributing to the cytotoxic potency of 17-AAG by decreasing the required "apoptotic threshold" in bladder cancer cells [ 38].
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Awareness of time in its three categories of past, present, and future has decisively contributed to man's success in the struggle for existence.
We believe that cloud-assisted architecture can decisively contribute to event monitoring performance improvement.
Firms' strategic movements can decisively contribute to the definition of the DD.
This can decisively contribute to not unnecessarily putting efforts in approaches which are subsequently rejected by the competent authorities.
Furthermore, the local tumour microenvironment has been shown to decisively contribute to cancer growth, metastasis, and progression to resistance (Bissell et al. 2002; Wiseman and Werb 2002).
Further investigation of relevant laminin epitopes in pathogenic autoimmunity would facilitate the development of appropriate diagnostic tools for thorough characterization of patients' antibody specificities and should decisively contribute to designing more specific therapeutic interventions.
The cases described in this paper are mainly initiatives aiming to change social practices, as such they are not social innovations yet, but they have the potential to have a broad impact changing social practices (within their respective target groups)—i.e. to become, or decisively contribute to, social innovations.
The authors argued that the "editing" of proline residues can decisively contribute to preorganize the conformation of a polypeptide chain and to enhance protein stability by lowering the entropic costs during protein folding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com