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On the other hand, the GSH levels within the cell were shown to act as a decisive resistance barrier to cisplatin, reducing the induction of DNA damage in the treated cells.
It is therefore hardly surprising that the experience of the public sector reform model has been characterized by the decisive resistance by the employees, leading to delays and unplanned changes in implementation.
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There is a decisive mood of resistance in America – a backlash to the status quo.
Aiming to decode the molecular mechanisms decisive for melanoma resistance, we took advantage of large and differentiated tumor spheroids which, when integrated into organotypic skin reconstructs, histologically show high similarity to primary cutaneous human melanoma metastases.
Whether the decisive parameter for resistance or resilience is the number of distinct clonal lineages or the number of different genetic variants (alleles) they bear, or both, may lead to drastically different priorities and plans to protect, manage or even restore populations of clonal organisms.
"A more decisive, prompt decision might have avoided some of the resistance that developed," Justice Stevens said.
Operation Goranboy was a large-scale Azerbaijani offensive in the summer of 1992 aimed at taking control over the entire Nagorno-Karabakh and putting a decisive end to the resistance.
In a recent paper, cfr gene has been described to play a decisive role in mediating resistance to linezolid [ 11].
From these observations and the hub gene-specific subgenome distribution in modules A and B we reason that subgenome D contributions may play a decisive role in overall resistance to F. graminearum.
The increased haematological toxicity is indicative of the importance of O-meG, and it is reasonable to speculate that factors downstream of O-meG, such as MMR and anti-apoptotic factors, and/or other TMZ-induced DNA lesions may have decisive functions in the resistance of melanoma to TMZ.
Many experimental evidences prove that both p53 and MDR-1 play decisive roles in chemo-resistance [ 13, 40].
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