An experimental investigation on this aspect may further provide more decisive observation in drug target identification and better understanding of the pathophysiology of T2D and its complications.
Certainly it is possible that other, as of yet unrecognized direct or indirect consequences of the absence of CLIC4, both in renal and in extrarenal tissues, may have a decisive impact on these observations Our original hypothesis that CLIC4 contributes substantially to fibrosis and long-term kidney scarring following injury is not persuasively supported by our data.
These observations highlight the decisive role played by the Tde DNase toxins and their cognate immunity proteins in the fitness of A. tumefaciens during the colonization of the plant host.
It was observed "how decisive he was: how accurate, without any effort or formality: what an extraordinary power of observation lay at the base of many of his casual or incidental remarks".
The decisive event that allowed the observation of cells was the invention of the microscope in the 17th century, after which interest in the "invisible" world was stimulated.
This observation is definitely decisive for the profitability of a geothermal power plant.
Then he went to the point, without wasted motion … In the case of the louse discovery, Nicolle had carried out no more than a half-dozen decisive experiments after years of observation of the disease and its epidemiology.
These observations can have a decisive impact on urban planning, human comfort and health.
When divergence was found between the information gained from the ward leader and the field observations, the observations were decisive – as information obtained through interviews with the ward leader was more likely to be biased by the individual leader's interpretations of the team concept.
